Eunuchoid Treated with Gonadotrophins

Circulating levels of gonadotrophins in immature mice treated neonatally with antisera to gonadotrophins.

Transgenic animals and gonadotrophins.

A variety of transgenic animal models has been developed to elucidate in vivo the functions of gonadotrophin genes. Some of these have focused on regulatory aspects through expression of gonadotrophin subunit promoter-driven reporter genes. Others have been carried out by overexpression or targeted disruption of specific gonadotrophin subunit genes, or by eliminating pituitary gonadotroph cells...

Outcome from consecutive in-vitro fertilization/intracytoplasmic sperm injection attempts in the final group treated with urinary gonadotrophins and the first group treated with recombinant follicle stimulating hormone.

In the absence of specific dose equivalency data, the aim of this study was to compare the clinical results during the cross-over from menopausal urinary products (human menopausal gonadotrophin; HMG) to recombinant follicle stimulating hormone (FSH) follitrophin beta (FSHr) in order to determine whether the manufacturer's recommendation for equivalence of ampoule to ampoule (50 IU FSHr:75 IU H...

Ovarian sensitivity to exogenous gonadotrophins in phenobarbital treated unilaterally ovariectomized albino rats.

Adult cycling female rats were hemispayed and administered with 7.5 mg phenobarbital/100 gm body weight for 15 days. 5IU FSH or FSH+LH per 100 gm body weight was administered from day 13 to 15 to the hemispayed phenobarbital treated rats. Phenobarbital inhibits the ovarian compensatory hypertrophy significantly and increases the cholesterol and lipid levels in the ovary. Administration of FSH a...

Serum gonadotrophins in Down's syndrome.

Serum levels of follicle stimulating hormone (FSH) and luteinising hormone (LH) in institutionalised male patients with Down's syndrome (DS) have been found to be significantly higher than in age matched controls from the same institution. This difference is found in patients both under and over 30 years of age with respect to FSH levels, but the increase in LH levels is confined to patients wi...